Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears
نویسندگان
چکیده
منابع مشابه
Skeletal Muscle Atrophy and Fatty Infiltration after Massive Rotator Cuff Tears in a Novel Rat Model
INTRODUCTION: Rotator cuff tears (RCT) are the most common tendon injury seen in orthopedic patients. Although small tears are amenable to arthroscopic repair, massive RCT repairs can result in re-tears and poor clinical outcomes. Muscle atrophy and fatty infiltration in rotator cuff muscles are major complications of chronic massive RCT and are thought to be among the factors responsible for t...
متن کاملInvestigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury.
BACKGROUND rotator cuff muscle atrophy, fibrosis and fatty infiltration are common complications after large and massive rotator cuff tears. Currently, there are no effective treatments for these muscle pathologies after injury. Furthermore, the cellular source for fibrotic and adipose tissues in rotator cuff muscle after injury remains unknown. In this study, we proposed that two groups of mus...
متن کاملInhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice
Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle plasticity and contraction strength. These changes in the mechanical properties of the affected muscle render surgical repair of RCT highly formidable. Therefore, it is important to learn more about the pathology of fatt...
متن کاملMuscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model.
INTRODUCTION rotator cuff tears (RCTs) are the most common tendon injury seen in orthopedic patients. Muscle atrophy and fatty infiltration of the muscle are crucial factors that dictate the outcome following rotator cuff surgery. Though less studied in humans, rotator cuff muscle fibrosis has been seen in animal models as well and may influence outcomes as well. The purpose of this study was t...
متن کاملA Prospective, Quantitative Evaluation of Fatty Infiltration Before and After Rotator Cuff Repair
BACKGROUND Current evaluation of muscle fatty infiltration has been limited by subjective classifications. Quantitative fat evaluation through magnetic resonance imaging (MRI) may allow for an improved longitudinal evaluation of the effect of surgical repair on the progression of fatty infiltration. HYPOTHESES We hypothesized that (1) patients with isolated full-thickness supraspinatus tendon...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2016
ISSN: 0736-0266
DOI: 10.1002/jor.23384